Dr. William G. Paterson

Dr. Paterson's CIHR-funded research lab focuses on the physiology and pathophysiology of the esophagus, using a spectrum of methodologies ranging from whole organ motility recordings to single cell intracellular and patch clamp recordings, ion imaging and various morphological techniques. Recently, his laboratory has made important new discoveries concerning the cellular mechanisms whereby the lower esophageal sphincter maintains tone and relaxes upon neural stimulation.

This specialized muscle plays a key role in preventing reflux of acid from the stomach, but must relax when one swallows so that food can pass unimpeded into the stomach. When this muscle fails to maintain its tone, acid reflux ensues, which results in inflammation of the lining of the esophagus (reflux esophagitis). On the other hand, if swallow-induced relaxation fails, the patient will have problems with food sticking in the chest. Understanding the physiology of this muscle is therefore crucial to the development of effective treatments for these common and troublesome diseases.

In addition, Dr. Paterson's lab has developed a model of reflux esophagitis and has used this to make novel discoveries on the role of mast cell-derived mediators in the neuromuscular dysfunction that complicates esophagitis. His lab has found that mast cell-derived inflammatory mediators induce esophageal shortening by causing contraction of the longitudinal muscle layer, probably via the release of Substance P or other neurokinins. This may have important clinical relevance with respect to the etiology of hiatus hernia and esophageal chest pain. In parallel, Dr. Paterson conducts a number of clinical projects in humans, focused mainly on gastroesophageal reflux disease and functional motor and sensory disorders of the GI tract

Early in his career, Dr. Paterson's research contributions were recognized with a Career Scientist Award from the Ontario Ministry of Health, and the Queen's University's Basmajian Award. More recently, he was recipient of the Canadian Association of Gastroenterology Research Excellence Award, as well as the Janssen International Award in Gastroenterology. As PI on the first CIHR strategic research training grant in digestive sciences, he is actively involved in the research training of new Canadian scientists.

For further information, please contact Dr. William G. Paterson using the Email contact form or by phone at 613 533-2000